ABSTRACT
At the beginning of 2020, a new type of Coronavirus (Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)) dismayed the world and led to public health emergencies. This virus has caused a remarkable percentage of morbidity and mortality. Also, the lack of an effective treatment to fight this virus is another concern that should be given attention. Herbal medicines and purified natural products have been reported for their antiviral activity against SARS-CoV-2. In this study, molecular docking of effective compounds in the extracts and essential oils of Zingiber officinale, Glycyrrhiza glabra Sambucus nigra, Panax ginseng Ocimum basilicum, and Origanum vulgare was carried out to investigate their binding to the X-ray structure of the ACE2 binding domain of SARSCoV-2. The Glide docking program was utilized for molecular docking with standard precision (SP) and extra precision (XP). Finally, 7 compounds-mainly belong to Panax ginseng-showed a higher docking score than some known antiviral compounds. Floralginsenoside B, which is extracted from Panax ginseng, indicated a strong binding affinity (-8.618 kcal/mol) to the crucial residues of the receptor binding domain of SARS-CoV-2 comparing to Doravirine (-7.2 kcal/mol), Hetacillin (-7.1 kcal/mol), Ketoprofen (-7.0 kcal/mol), and Mefloquine (-7.0 kcal/mol) reported in previous articles. Based on the excellent binding affinities of these herbal compounds, we concluded that these phytochemicals could be promising candidates for fighting against the COVID-19 pandemic. © 2021 by the authors.
ABSTRACT
Background and Aim: Experience is obtained as one of the most valuable human assets in different situations and conditions and helps organizations to achieve their strategic goals. The present study was conducted at the Baqiyatallah University of Medical Sciences with aim of designing and compiling a comprehensive empirical program in confronting the COVID-19 crisis. Methods: This applied research was conducted in qualitative and quantitative methods. The statistical population included 24 university experts, managers and executive experts at Baqiyatallah University of Medical Sciences in April and May 2020. All of these individuals were involved in coping with Covid-19. By holding various meetings with the researchers, and obtaining the opinions of experts with the Delphi technique;the events of the crisis and their main axes in dealing with Covid-19 were counted. Results: Findings show 5 areas and 25 main axes of the event (crisis with domestic, regional, international sensitivity and major damage);18 events in the field of command and leadership, 15 events in research, 9 events in training, 22 events in healthcare, 6 events in support in dealing with Covid-19. Healthcare is the most common (22) and spirituality is the lowest (2) frequency. Conclusion: Due to the Covid-19 crisis, healthcare is the most important axis (22 events) and it is necessary to record experience and document for using in similar crises. This empiricism can be used as a basis for managers' planning to implement experience documentation in the organization. © 2020 Baqiyatallah University of Medical Sciences. All rights reserved.